Discretesex


Growing evidence suggests the involvement of glutamate in mood disorders and in the response to antidepressants.

However, there is no information regarding a hypothesized sex-dependent glutamatergic modulation following treatment in animal models of depression.

We comparatively assayed in male and female Flinders and control Sprague–Dawley rats glutamate and aspartate tissue levels in the prefrontal cortex, hippocampus and nucleus accumbens following 14-day treatment with either 10 mg/kg clomipramine or mirtazapine, intraperitoneally.

Clomipramine increased cortical glutamate in both sexes and hippocampal glutamate only in female Flinders rodents.

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